Selected Publications
2022
Eva E. Lancaster, Vladimir I. Vladimirov, Brien P. Riley, Joseph W. Landry, Roxann Roberson-Nay & Timothy P. York (2022) Large-scale integration of DNA methylation and gene expression array platforms identifies both cis and trans relationships, Epigenetics, 17:12, 1753-1773, DOI: 10.1080/15592294.2022.2079293 [pdf]
Understanding the genetics of peripartum depression: Research challenges, strategies, and opportunities. Lancaster EE, Lapato DM, Peterson RE. Front Genet. 2022 Nov 17;13:1022188. doi: 10.3389/fgene.2022.1022188. eCollection 2022. PMID: 36468033 Free PMC article. Review. [pdf]
Genetic and environmental etiology of drinking motives in college students. Savage JE, Peterson RE, Aliev F; Spit for Science Working Group; Dick DM. Alcohol Clin Exp Res. 2022 Oct;46(10):1783-1796. doi: 10.1111/acer.14930. Epub 2022 Oct 18. PMID: 36256465 Free PMC article. [pdf]
Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits. Lencz T, Sabatello M, Docherty A, Peterson RE, Soda T, Austin J, Bierut L, Crepaz-Keay D, Curtis D, Degenhardt F, Huckins L, Lazaro-Munoz G, Mattheisen M, Meiser B, Peay H, Rietschel M, Walss-Bass C, Davis LK. Lancet Psychiatry. 2022 Oct;9(10):838-844. doi: 10.1016/S2215-0366(22)00157-2. Epub 2022 Aug 2. PMID: 35931093 Review. [pdf]
Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System. Bigdeli TB, Voloudakis G, Barr PB, Gorman BR, Genovese G, Peterson RE, Burstein DE, Velicu VI, Li Y, Gupta R, Mattheisen M, Tomasi S, Rajeevan N, Sayward F, Radhakrishnan K, Natarajan S, Malhotra AK, Shi Y, Zhao H, Kosten TR, Concato J, O'Leary TJ, Przygodzki R, Gleason T, Pyarajan S, Brophy M, Huang GD, Muralidhar S, Gaziano JM, Aslan M, Fanous AH, Harvey PD, Roussos P; Cooperative Studies Program (CSP) #572 and Million Veteran Program (MVP). JAMA Psychiatry. 2022 Sep 14;79(11):1092-101. Doi: 10.1001/jamapsychiatry.2022.2742. Online ahead of print. PMID: 36103194 Free PMC article. [pdf]
Bountress KE, Brick LA, Sheerin C, Grotzinger A, Bustamante D, Hawn SE, Gillespie N, Kirkpatrick RM, Kranzler H, Morey R, Edenberg HJ, Maihofer AX, Disner S, Ashley-Koch A, Peterson R, Lori A, Stein DJ, Kimbrel N, Nievergelt C, Andreassen OA, Luykx J, Javanbakht A, Youssef NA; Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group, Amstadter AB. Drug Alcohol Depend. 2022 May 1;234:109430. doi: 10.1016/j.drugalcdep.2022.109430. Epub 2022 Mar 28. PMID: 35367939 [pdf]
Schork, A.J., Peterson, R. E., Dahl, A., Cai, N., & Kendler, K. S. (2022). Indirect paths from genetics to education. Nature Genetics, 54(4), 372–373. https://doi.org/10.1038/s41588-021-00999-5 [pdf]
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. Jami ES, Hammerschlag AR, Ip HF, Allegrini AG, Benyamin B, Border R, Diemer EW, Jiang C, Karhunen V, Lu Y, Lu Q, Mallard TT, Mishra PP, Nolte IM, Palviainen T, Peterson RE, Sallis HM, Shabalin AA, Tate AE, Thiering E, Vilor-Tejedor N, Wang C, Zhou A, Adkins DE, Alemany S, Ask H, Chen Q, Corley RP, Ehli EA, Evans LM, Havdahl A, Hagenbeek FA, Hakulinen C, Henders AK, Hottenga JJ, Korhonen T, Mamun A, Marrington S, Neumann A, Rimfeld K, Rivadeneira F, Silberg JL, van Beijsterveldt CE, Vuoksimaa E, Whipp AM, Tong X, Andreassen OA, Boomsma DI, Brown SA, Burt SA, Copeland W, Dick DM, Harden KP, Harris KM, Hartman CA, Heinrich J, Hewitt JK, Hopfer C, Hypponen E, Jarvelin MR, Kaprio J, Keltikangas-Järvinen L, Klump KL, Krauter K, Kuja-Halkola R, Larsson H, Lehtimäki T, Lichtenstein P, Lundström S, Maes HH, Magnus P, Munafò MR, Najman JM, Njølstad PR, Oldehinkel AJ, Pennell CE, Plomin R, Reichborn-Kjennerud T, Reynolds C, Rose RJ, Smolen A, Snieder H, Stallings M, Standl M, Sunyer J, Tiemeier H, Wadsworth SJ, Wall TL, Whitehouse AJO, Williams GM, Ystrøm E, Nivard MG, Bartels M, Middeldorp CM. J Am Acad Child Adolesc Psychiatry. 2022 Apr 1:S0890-8567(22)00179-4. doi: 10.1016/j.jaac.2021.11.035. Online ahead of print. PMID: 35378236 [pdf]
2021
Sheerin CM, Lancaster EE, York TP, Smalling A, Walker J, Danielson CK, Amstadter AB. (2021) Epigenome-wide study of PTSD symptom severity in a treatment-seeking adolescent sample. The Journal of Traumatic Stress. doi: 10.1002/jts.22655 [pdf]
Polygenic Score for Cigarette Smoking is Associated with Ever Electronic-Cigarette Use in a
College-Aged Sample. Cooke ME, Clifford JS, Do EK, Gilman JM; Spit for Science Working
group, Maes HH, Peterson RE, Prom-Wormley EC, Evins AE, Schuster RM. Addiction. 2021
Oct 11. PMID: 34636095. [pdf]
Lancaster, E. E., Lapato, D. M., Jackson-Cook, C., Strauss, J. F., Roberson-Nay, R., & York, T. P. (2021). Maternal biological age assessed in early pregnancy is associated with gestational age at birth. Scientific Reports, 11(1), 15440–15440. https://doi.org/10.1038/s41598-021-94281-7 [pdf]
The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide
Association Study. Giannakopoulou O, Lin K, Meng X, Su MH, Kuo PH, Peterson RE, Awasthi
S, Moscati A, Coleman JRI, Bass N, Millwood IY, Chen Y, Chen Z, Chen HC, Lu ML, Huang
MC, Chen CH, Stahl EA, Loos RJF, Mullins N, Ursano RJ, Kessler RC, Stein MB, Sen S, Scott
LJ, Burmeister M, Fang Y, Tyrrell J, Jiang Y, Tian C, McIntosh AM, Ripke S, Dunn EC, Kendler
KS, Walters RG, Lewis CM, Kuchenbaecker K; 23andMe Research Team, China Kadoorie
Biobank Collaborative Group, and Major Depressive Disorder Working Group of the
Psychiatric Genomics Consortium. JAMA Psychiatry. 2021 Sep 29. PMID: 34586374. [pdf]
Lapato, D.M., Wolf, H. M., Lancaster, E. E., Roberson-Nay, R., & York, T. P. (2021). A Primer on DNA Methylation and Its Potential to Impact Maternal Depression Risk and Assessment During Pregnancy and the Postpartum. The Journal of Perinatal & Neonatal Nursing, 35(1), 4–7. https://doi.org/10.1097/JPN.0000000000000528 [pdf]
Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric
Genomics Consortium. Peterson RE, Bigdeli TB, Ripke S, Bacanu SA, Gejman PV, Levinson
DF, Li QS, Rujescu D, Rietschel M, Weinberger DR, Straub RE, Walters JTR, Owen MJ,
O'Donovan MC, Mowry BJ, Ophoff RA, Andreassen OA, Esko T, Petryshen TL, Kendler KS;
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Fanous AH. J Psychiatr
Res. 2021 Feb 18;137:215-224. PMID: 33691233. [pdf]
Sheerin, C. M., Lancaster, E. E., York, T. P., Walker, J., Danielson, C. K., & Amstadter, A. B. (2021). Epigenome‐Wide Study of Posttraumatic Stress Disorder Symptom Severity in a Treatment‐Seeking Adolescent Sample. Journal of Traumatic Stress, 34(3), 607–615. https://doi.org/10.1002/jts.22655 [pdf]
Investigation of convergent and divergent genetic influences underlying schizophrenia and
alcohol use disorder. Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR,
Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous
AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J,
Edenberg HJ, Agrawal A. Psychol Med. 2021 Jul 7:1-9. PMID: 34231451. [pdf]
The Genetics of Major Depression: Perspectives on the State of Research and Opportunities for
Precision Medicine. RE Peterson. Psychiatric Annals. 2021; 51(4):165-169. [pdf]
Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Joanna
Martin, Ekaterina A. Khramtsova, Slavina B. Goleva, Roseann E. Peterson, et al., Barbara E.
Stranger, Lea K. Davis on behalf of the Sex Differences Cross-Disorder Analysis Group of the
Psychiatric Genomics Consortium. Biological Psychiatry. January 8, 2021. [pdf]
2020
Roberson-Nay, R., Lapato, D.M., Wolen, A.R. et al. An epigenome-wide association study of early-onset major depression in monozygotic twins. Transl Psychiatry 10, 301 (2020). https://doi.org/10.1038/s41398-020-00984-2 [pdf]
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Coleman JRI, Peyrot WJ, Purves KL, Davis KAS, Rayner
C, Choi SW, Hübel C, Gaspar HA, Kan C, Van der Auwera S, Adams MJ, Lyall DM, Choi KW; on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn EC, Vassos E, Danese A, Maughan B, Grabe HJ, Lewis CM, O'Reilly PF, McIntosh AM, Smith DJ, Wray NR, Hotopf M, Eley TC, Breen G. Mol Psychiatry. 2020 Jul;25(7):1430-1446. PMID: 31969693. [pdf]
A large-scale genome-wide association study meta-analysis of cannabis use disorder. Johnson
EC, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Davis LK,
Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A. Lancet Psychiatry.
2020 Oct 20:S2215-0366(20)30339-4. PMID: 33096046. [pdf]
Leveraging genome-wide data to investigate differences between opioid use vs. opioid
dependence in 41,176 individuals from the Psychiatric Genomics Consortium. Polimanti R,
Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli
TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM,
Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer
CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes
HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb
BT, Wetherill L; Psychiatric Genomics Consortium Substance Use Disorders Workgroup,
Edenberg HJ, Agrawal A, Gelernter J. Mol Psychiatry. 2020 Aug;25(8):1673-1687. PMID:
32099098. [pdf]
2019
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric
Disorders. Cross-Disorder Group of the Psychiatric Genomics Consortium. Cell. 2019 Dec
12;179(7):1469-1482.e11. PMID: 31835028. [pdf]
Invited Primer: Genome-wide association studies in ancestrally diverse populations:
opportunities, methods, pitfalls, and recommendations. RE Peterson, K Kuchenbaecker, RK
Walters, CY Chen, AB Popejoy, S Periyasamy, M Lam, C Iyegbe, RJ Strawbridge, L Brick, C
Carey, A Martin, JL Meyers, J Su, J Chen, AC Edwards, A Kalungi, N Koen, L Majara, E
Schwarz, J Smoller, EA Stahl, P Sullivan, E Vassos, B Mowry, M Prieto, A Cuellar-Barboza, TB
Bigdeli, HJ Edenberg, H Huang, LE Duncan. Cell. 2019 Oct 17;179(3):589-603.
PMID:31607513, PMCID: PMC6939869. [pdf]
Contributions of common genetic variants to risk of schizophrenia among individuals of African
and Latino ancestry. Bigdeli TB, Genovese G, Georgakopoulos P, Meyers JL, Peterson RE,
Iyegbe CO, Medeiros H, Valderrama J, Achtyes ED, Kotov R, Stahl EA, Abbott C, Azevedo MH,
Belliveau RA, Bevilacqua E, Bromet EJ, Byerley W, Carvalho CB, Chapman SB, DeLisi LE,
Dumont AL, O'Dushlaine C, Evgrafov OV, Fochtmann LJ, Gage D, Kennedy JL, Kinkead B,
Macedo A, Moran JL, Morley CP, Dewan MJ, Nemesh J, Perkins DO, Purcell SM, Rakofsky JJ,
Scolnick EM, Sklar BM, Sklar P, Smoller JW, Sullivan PF, Macciardi F, Marder SR, Gur RC,
Gur RE, Braff DL, Nicolini H, Escamilla MA, Vawter MP, Sobell JL, Malaspina D, Lehrer DS,
Buckley PF, Rapaport MH, Knowles JA, Fanous AH, Pato MT, McCarroll SA, Pato CN. Mol
Psychiatry. 2019 Oct 7. PMID: 31591465. [pdf]
Analysis of polygenic risk score usage and performance in diverse human populations. Duncan L,
Shen H, Gelaye B, Meijsen J, Ressler K, Feldman M, Peterson R, Domingue B. Nat Commun.
2019 Jul 25;10(1):3328. PMID: 31346163, PMCID: PMC6658471. [pdf]
International Society of Psychiatric Genetics Ethics Committee: Issues facing us. Lázaro-Muñoz
G, Sabatello M, Huckins L, Peay H, Degenhardt F, Meiser B, Lencz T, Soda T, Docherty A,
Crepaz-Keay D, Austin J, Peterson RE, Davis LK; ISPG Ethics Committee. Am J Med Genet B
Neuropsychiatr Genet. 2019 May 23. PMID: 31124312, PMCID: PMC6861601. [pdf]
Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE.
Docherty AR, Moscati A, Bigdeli TB, Edwards AC, Peterson RE, Adkins DE, Anderson JS,
Flint J, Kendler KS, Bacanu SA. Psychol Med. 2019 Apr 2:1-6. PMID: 30935430, PMCID:
PMC6774907. [pdf]
Evidence of causal effect of major depression on alcohol dependence: findings from the
psychiatric genomics consortium. Polimanti R*, Peterson RE*, Ong JS, MacGregor S, Edwards
AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H,
Medland SE, Streit F; Major Depressive Disorder Working Group of the Psychiatric Genomics
Consortium, Agrawal A, Edenberg HJ, Kendler KS, Lewis CM, Sullivan PF, Wray NR, Gelernter
J, Derks EM. Psychol Med. 2019 Apr 1:1-9. PMID: 30929657, PMCID: PMC6565601. [pdf]
2018
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with
psychiatric disorders. Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins
AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke
TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J,
Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S,
Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti
J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM,
McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu
E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J,
Thomas N, Wang JC, Webb BT, et al, Gelernter J, Edenberg HJ, Agrawal A. Nat Neurosci. 2018
Dec;21(12):1656-1669. PMID: 30482948. [pdf]
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of
major depression. Nat Genet. 2018 Apr 26. PMID: 29700475. [pdf]
Peterson RE, Cai N, Dahl AW, Bigdeli TB, Edwards AC, Webb BT, Bacanu SA, Zaitlen N, Flint J, Kendler KS. Molecular Genetic Analysis Subdivided by Adversity Exposure Suggests Etiologic Heterogeneity in Major Depression. American Journal of Psychiatry. 2018 Mar 2. PMC5988935. [pdf]
2017
Docherty AR, Moscati A, Dick D, Savage JE, Salvatore JE, Cooke M, Aliev F, Moore AA,
Edwards AC, Riley BP, Adkins DE, Peterson R, Webb BT, Bacanu SA, Kendler KS. Polygenic
prediction of the phenome, across ancestry, in emerging adulthood. Psychol Med. 2017 Nov 27:1-
10. PMID: 29173193. [pdf]
van Loo HM, Van Borkulo CD, Peterson RE, Fried EI, Aggen SH, Borsboom D, Kendler KS.
Robust symptom networks in recurrent major depression across different levels of genetic and
environmental risk. J Affect Disord. 2017 Oct 29;227:313-322. PMID: 29132074. [pdf]
Peterson RE. Leveraging molecular genetic approaches to yield insights into major depression
etiology and clinical presentation. JAMA Psychiatry. 2017 Oct 18. PMID: 29049499. [pdf]
Edwards AC, Docherty AR, Moscati A, Bigdeli TB, Peterson RE, Webb BT, Bacanu SA,
Hettema JM, Flint J, Kendler KS. Polygenic risk for severe psychopathology among Europeans is
associated with major depressive disorder in Han Chinese women. Psychol Med. 2017 Oct 3:1-
13. PMID: 28969721. [pdf]
Peterson RE, Edwards AC, Bacanu SA, Dick DM, Kendler KS, Webb BT. The utility of
empirically assigning ancestry groups in cross-population genetic studies of addiction. Am J
Addict. 2017 Aug;26(5):494-501. PMID: 28714599. PMC5646819. [pdf]
T B Bigdeli, S Ripke, R E Peterson, et al, B T Webb, M M Weissman, J Wellmann, G
Willemsen, S H Witt, D F Levinson, C M Lewis, N R Wray, J Flint, P F Sullivan and K S
Kendler on behalf of the CONVERGE consortium and Major Depressive Disorder Working
Group of the Psychiatric Genomics Consortium. Genetic effects influencing risk for major
depressive disorder in China and Europe. Transl Psychiatry 2017 March 28;7: e1074. PMID:
28350396. PMC5404611. [pdf]
Peterson RE, Cai N, Bigdeli TB, Li Y, Reimers M, Nikulova A, Webb BT, Bacanu SA, Riley BP, Flint J, Kendler KS. The Genetic Architecture of Major Depressive Disorder in Han Chinese Women. JAMA Psychiatry. 2017 Feb 1;74(2):162-168. PMID: 28002544. PMC5319866. [pdf]
Clark SL, McClay JL, Adkins DE, Kumar G, Aberg KA, Nerella S, Xie L, Collins AL, Crowley
JJ, Quackenbush CR, Hilliard CE, Shabalin AA, Vrieze SI, Peterson RE, Copeland WE, Silberg
JL, McGue M, Maes H, Iacono WG, Sullivan PF, Costello EJ, van den Oord EJ. Deep
Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol
Dependence. Alcohol Clin Exp Res. 2017 Feb 14. PMID: 28196272. PMC5378639. [pdf]
Docherty AR, Edwards AC, Yang F, Peterson RE, Sawyers C, Adkins DE, Moore AA, Webb
BT, Bacanu SA, Flint J, Kendler KS. Age of onset and family history as indicators of polygenic
risk for major depression. Depress Anxiety. 2017 Feb 2. PMID: 28152564. [pdf]
2016
A R Docherty, A Moscati, R Peterson, A C Edwards, D E Adkins, S A Bacanu, T B Bigdeli, B T Webb, J Flint and K S Kendler. SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE. Transl Psychiatry 2016 Oct 25;6(10):e926. [pdf]
Edwards AE, Aggen SE, Cai N, Bigdeli TB, Peterson RE, Converge Consortium, Flint J,
Kendler KS. Chronicity of depression and molecular markers in a large sample of Chinese
women. Depression and Anxiety. 2016 April 25. PMID: 27110890, PMCID: PMC5079854. [pdf]
2015
CONVERGE Consortium. Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature 2015. Jul 30;523(7562):588-91. Epub 2015 Jul 15. PMID: 26176920. [pdf]
2014
Peterson RE, Maes HH, Lin P, Kramer JR, Hesselbrock VM, Bauer LO, Nurnberger JI
Jr, Edenberg HJ, Dick DM, Webb BT. On the association of common and rare genetic variation
influencing body mass index: a combined SNP and CNV analysis. BMC Genomics 2014, 15:368.
PMID: 24884913. [pdf]